Novartis unveils new centered technique, underpinned by eight potential multi-billion greenback peak gross sales manufacturers & deep pipeline, at Meet the Administration occasion

• Transformation to pure-play Progressive Medicines firm nears completion

• Focusing technique on 5 core Therapeutic Areas, key expertise platforms, and the US

• Advancing eight in-market manufacturers with multi-billion greenback peak gross sales potential and prioritizing pipeline to concentrate on high-value NMEs

• Persevering with to ship rising gross sales, Core Op Inc, and money flows with constant shareholder pleasant capital allocation

Basel, September 22, 2022 — Novartis executives are assembly traders and business analysts in Basel at this time, sharing insights into the up to date firm technique on the annual Meet Novartis Administration occasion. The assembly will enable individuals to study extra about Novartis journey to unite expertise management in Analysis and Growth with novel entry approaches, serving to to alleviate a few of society’s best illness burdens.

“Novartis is reworking right into a ‘pure-play’ Progressive Medicines firm. Our technique is targeted on 5 core engaging therapeutic areas, key expertise platforms, and the US market, with the intention to extend worth per new molecular entity from our deep pipeline”, stated Vas Narasimhan, CEO of Novartis. “We are going to proceed to ship improved financials with +4% gross sales CAGR by means of 2027 and a Core Op Inc margin ~40%+ within the mid – long run. Our disciplined capital allocation will steadiness continued funding within the enterprise and returning capital to our shareholders”.

Novartis is implementing this technique with a transparent concentrate on 5 therapeutic areas for funding – cardiovascular, immunology, neuroscience, stable tumors and hematology. Novartis has a number of vital in-market and pipeline belongings in every of those areas, which characterize vital illness burden and have the biggest progress potential within the USD 1 Tn innovatives medicines market. Eight present in-market manufacturers, Cosentyx, Entresto, Zolgensma, Kisqali, Kesimpta, Leqvio, Pluvicto and Scemblix, every maintain multi-billion greenback peak gross sales potential.

Concentrate on US and different precedence geographies together with China, Germany, Japan
These eight manufacturers are underpinning progress throughout all key geographies, supporting Novartis aspiration to enhance aggressive positioning and organically construct its US enterprise to change into a top-five participant within the US by 2027. A ‘US-first’ mindset, growing share of US sufferers in medical trials and constructing functionality and expertise, amongst different actions, will allow Novartis to acheive this goal. Novartis additionally goals to be a top-three participant in China, a key progress marketplace for the following decade, whereas sustaining main positions in Germany and Japan.

Establishing Management throughout Key Know-how Platforms
The Novartis portfolio of medicines is shifting towards biologics and expertise platforms – recognizing their growing energy in tackling illness. Along with two established platforms in chemistry and biotherapeutics, three newer platforms – gene & cell remedy, radioligand remedy, and ‘xRNA’ – are being prioritized for continued funding into new R&D capabilities and manufacturing scale. With over 50 initiatives in exploratory to early medical growth, Novartis is effectively positioned to guide the business in creating these platforms and develop our enterprise presence.

Wealthy Growth Pipeline shifting to Excessive-Worth NMEs
Administration outlined its strategy to prioritization of Novartis wealthy pipeline. Rising business focus in 5 core remedy areas, in addition to renewed consideration to high-value belongings which have the potential to drive progress within the US, had been highlighted. The corporate showcased numerous catalysts set to drive newsflow within the mid & near-term:

• Kisqali (ribociclib);information from the NATALEE trial in adjuvant HER2-negative breast most cancers in each high- and intermediate-risk sufferers with breast most cancers in 2023.
• Iptacopan; first section 3 trial ends in sufferers with paroxysmal nocturnal hemoglobinuria later this 12 months with extra information readouts in different indications in 2023.
• Pluvicto; section 3 information from the PSMAfore trial in metastatic castration-resistant prostate most cancers late 2022/early 2023.
• Remibrutinib; section 3 information from two trials in persistent spontaneous urticaria in 2024 and from two section 3 trials in relapsing a number of sclerosis in 2025.
• Scemblix (asciminib);information from the CML-CP trial in first line CML in 2024.

The excessive worth late stage growth pipeline can be anticipated to ship a big quantity information readouts within the 2024-25 timeframe. Targeted on driving operational excellence, Novartis shared insights into chosen early medical packages the place strengthening integration inside R&D will assist speed up growth and launch operational effectivity.

Persevering with to ship improved financials
The rising enterprise, with gross sales anticipated to enhance +4% CAGR 2021-2027, coupled with introduced strategic strikes, will allow bettering monetary efficiency within the coming years. Core working revenue margin is anticipated to extend to ~40+% within the mid – long run, together with the absorption of company prices. This improved profitability is ready to drive improved Free Money Stream and Return on Invested Capital (ROIC).
Administration outlined Novartis disciplined shareholder-focused strategy to capital allocation, highlighting USD 53bn distributed to shareholders from 2017-2021. Substantial money era will proceed to permit us to steadiness returning capital to shareholders with investing within the enterprise.

Separation of Sandoz, by way of 100% spin-off, is in one of the best pursuits of shareholders
The Sandoz spin-off transaction is anticipated to be accomplished in H2 2023, supporting Novartis ambitions in changing into a totally centered medicines firm. Sandoz is deliberate to be included in Switzerland and to be listed on the SIX Swiss Change, with an American Depositary Receipt (ADR) program within the US, and anticipated to change into the publicly traded #1 European generics firm¹ and a worldwide chief in biosimilars based mostly in Switzerland.

Strengthening foundations – ESG
Aiming to proceed strengthening the foundations of its enterprise together with bettering broad entry to innovation for sufferers, Novartis outlined key parts of its strategy to ESG. These embody guaranteeing entry methods are included in all new product launches and growing the variety of sufferers in medical trials, in addition to guaranteeing revolutionary medicines attain extra sufferers in low and center revenue nations sooner; uncared for tropical illnesses stay a spotlight for innovation. Novartis will proceed to prioritize its main place in third-party ESG scores and confirmed that its revolutionary sustainability linked bond targets are on observe.

Disclaimer

This press launch accommodates forward-looking statements throughout the which means of the USA Personal Securities Litigation Reform Act of 1995. Ahead-looking statements can usually be recognized by phrases similar to “technique,” “aspiration,” “goals,” “bettering,” “ambition,” “potential,” “can,” “will,” “plan,” “could,” “may,” “would,” “count on,” “anticipate,” “search,” “look ahead,” “consider,” “dedicated,” “investigational,” “pipeline,” “launch,” or comparable phrases, or by specific or implied discussions relating to potential advertising approvals, new indications or labeling for the investigational or accredited merchandise described on this press launch; relating to potential future revenues from such merchandise; relating to the potential completion of the proposed spin-off of Sandoz; relating to the long run business efficiency of Novartis or of Sandoz; relating to potential strategic advantages, synergies or alternatives from the proposed spin-off; relating to our expectations of an bettering monetary profile; relating to management throughout key expertise platforms; or relating to potential future progress in key geographies. You shouldn’t place undue reliance on these statements. Such forward-looking statements are based mostly on our present beliefs and expectations relating to future occasions, and are topic to vital recognized and unknown dangers and uncertainties. Ought to a number of of those dangers or uncertainties materialize, or ought to underlying assumptions show incorrect, precise outcomes could fluctuate materially from these set forth within the forward-looking statements. There may be no assure that the investigational or accredited merchandise described on this press launch will likely be submitted or accredited on the market or for any extra indications or labeling in any market, or at any explicit time. Nor can there be any assure that suchproducts will likely be commercially profitable sooner or later. Neither can there be any assure that the proposed spin-off will likely be accomplished within the anticipated type or throughout the anticipated timeframe or in any respect. Nor can there be any assure that we can enhance our monetary profile. Neither can there be any assure that we’ll obtain a management function throughout key expertise platforms or obtain progress in key geographies. Particularly, our expectations relating to our merchandise may very well be affected by, amongst different issues, the uncertainties inherent in analysis and growth, together with medical trial outcomes and extra evaluation of current medical information; an sudden failure to finish, or sudden delays in finishing, the proposed spin-off of Sandoz; an sudden failure or delay in realizing the potential strategic advantages, synergies or alternatives from the proposed spin-off; regulatory actions or delays or authorities regulation usually; a failure to enhance our monetary profile; a failure to attain a management function throughout key expertise platforms or obtain progress in key geographies; international developments towards well being care price containment, together with authorities, payor and basic public pricing and reimbursement pressures and necessities for elevated pricing transparency; our potential to acquire or preserve proprietary mental property safety; the actual prescribing preferences of physicians and sufferers; basic political, financial and enterprise circumstances, together with the consequences of and efforts to mitigate pandemic illnesses similar to COVID-19; security, high quality, information integrity or manufacturing points; potential or precise information safety and information privateness breaches, or disruptions of our data expertise programs, and different dangers and components referred to in Novartis AG’s present Kind 20-F on file with the US Securities and Change Fee. Novartis is offering the knowledge on this press launch as of this date and doesn’t undertake any obligation to replace any forward-looking statements contained on this press launch because of new data, future occasions or in any other case.

About Novartis

Novartis is reimagining medication to enhance and lengthen individuals’s lives. As a number one international medicines firm, we use revolutionary science and digital applied sciences to create transformative therapies in areas of nice medical want. In our quest to seek out new medicines, we persistently rank among the many world’s prime corporations investing in analysis and growth. Novartis merchandise attain almost 800 million individuals globally and we’re discovering revolutionary methods to develop entry to our newest therapies. About 108,000 individuals of greater than 140 nationalities work at Novartis all over the world. Discover out extra at https://www.novartis.com.

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¹ Primarily based on IQVIA product sales for mixed generics and biosimilars market, referring to March 2022

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